MovDisordV3, Main, Exploration, bibRecord, 000313

Balancing the basal ganglia circuitry: a possible new role for dopamine D2 receptors in health and disease.

Identifieur interne : 000313 ( Main/Exploration ); précédent : 000312; suivant : 000314

Balancing the basal ganglia circuitry: a possible new role for dopamine D2 receptors in health and disease.

Auteurs : Maxime Cazorla [États-Unis] ; Un Jung Kang [États-Unis] ; Christoph Kellendonk [États-Unis]

Source :

Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2015.

RBID : pubmed:26018615

Abstract

Current therapies for treating movement disorders such as Parkinson's disease are effective but limited by undesirable and intractable side effects. Developing more effective therapies will require better understanding of what causes basal ganglia dysregulation and why medication-induced side effects develop. Although basal ganglia have been extensively studied in the last decades, its circuit anatomy is very complex, and significant controversy exists as to how the interplay of different basal ganglia nuclei process motor information and output. We have recently identified the importance of an underappreciated collateral projection that bridges the striatal output direct pathway with the indirect pathway. These bridging collaterals are extremely plastic in the adult brain and are involved in the regulation of motor balance. Our findings add a new angle to the classical model of basal ganglia circuitry that could be exploited for the development of new therapies against movement disorders. In this Scientific Perspective, we describe the function of bridging collaterals and other recent discoveries that challenge the simplicity of the classical basal ganglia circuit model. We then discuss the potential implication of bridging collaterals in the pathophysiology of Parkinson's disease and schizophrenia. Because dopamine D2 receptors and striatal neuron excitability have been found to regulate the density of bridging collaterals, we propose that targeting these projections downstream of D2 receptors could be a possible strategy for the treatment of basal ganglia disorders. © 2015 International Parkinson and Movement Disorder Society.

DOI: 10.1002/mds.26282
PubMed: 26018615

Affiliations:

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Balancing the basal ganglia circuitry: a possible new role for dopamine D2 receptors in health and disease.</title>
<author><name sortKey="Cazorla, Maxime" sort="Cazorla, Maxime" uniqKey="Cazorla M" first="Maxime" last="Cazorla">Maxime Cazorla</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Psychiatry, Columbia University, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, Columbia University, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
</author>
<author><name sortKey="Kang, Un Jung" sort="Kang, Un Jung" uniqKey="Kang U" first="Un Jung" last="Kang">Un Jung Kang</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Neurology, Columbia University, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Columbia University, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
</author>
<author><name sortKey="Kellendonk, Christoph" sort="Kellendonk, Christoph" uniqKey="Kellendonk C" first="Christoph" last="Kellendonk">Christoph Kellendonk</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Psychiatry, Columbia University, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, Columbia University, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2015">2015</date>
<idno type="RBID">pubmed:26018615</idno>
<idno type="pmid">26018615</idno>
<idno type="doi">10.1002/mds.26282</idno>
<idno type="wicri:Area/PubMed/Corpus">000155</idno>
<idno type="wicri:Area/PubMed/Curation">000155</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000314</idno>
<idno type="wicri:Area/Ncbi/Merge">004363</idno>
<idno type="wicri:Area/Ncbi/Curation">004363</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">004363</idno>
<idno type="wicri:Area/Main/Merge">000313</idno>
<idno type="wicri:Area/Main/Curation">000313</idno>
<idno type="wicri:Area/Main/Exploration">000313</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Balancing the basal ganglia circuitry: a possible new role for dopamine D2 receptors in health and disease.</title>
<author><name sortKey="Cazorla, Maxime" sort="Cazorla, Maxime" uniqKey="Cazorla M" first="Maxime" last="Cazorla">Maxime Cazorla</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Psychiatry, Columbia University, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, Columbia University, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
</author>
<author><name sortKey="Kang, Un Jung" sort="Kang, Un Jung" uniqKey="Kang U" first="Un Jung" last="Kang">Un Jung Kang</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Neurology, Columbia University, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Columbia University, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
</author>
<author><name sortKey="Kellendonk, Christoph" sort="Kellendonk, Christoph" uniqKey="Kellendonk C" first="Christoph" last="Kellendonk">Christoph Kellendonk</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Psychiatry, Columbia University, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, Columbia University, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2015" type="published">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Current therapies for treating movement disorders such as Parkinson's disease are effective but limited by undesirable and intractable side effects. Developing more effective therapies will require better understanding of what causes basal ganglia dysregulation and why medication-induced side effects develop. Although basal ganglia have been extensively studied in the last decades, its circuit anatomy is very complex, and significant controversy exists as to how the interplay of different basal ganglia nuclei process motor information and output. We have recently identified the importance of an underappreciated collateral projection that bridges the striatal output direct pathway with the indirect pathway. These bridging collaterals are extremely plastic in the adult brain and are involved in the regulation of motor balance. Our findings add a new angle to the classical model of basal ganglia circuitry that could be exploited for the development of new therapies against movement disorders. In this Scientific Perspective, we describe the function of bridging collaterals and other recent discoveries that challenge the simplicity of the classical basal ganglia circuit model. We then discuss the potential implication of bridging collaterals in the pathophysiology of Parkinson's disease and schizophrenia. Because dopamine D2 receptors and striatal neuron excitability have been found to regulate the density of bridging collaterals, we propose that targeting these projections downstream of D2 receptors could be a possible strategy for the treatment of basal ganglia disorders. © 2015 International Parkinson and Movement Disorder Society.</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>État de New York</li>
</region>
<settlement><li>New York</li>
</settlement>
<orgName><li>Université Columbia</li>
</orgName>
</list>
<tree><country name="États-Unis"><region name="État de New York"><name sortKey="Cazorla, Maxime" sort="Cazorla, Maxime" uniqKey="Cazorla M" first="Maxime" last="Cazorla">Maxime Cazorla</name>
</region>
<name sortKey="Kang, Un Jung" sort="Kang, Un Jung" uniqKey="Kang U" first="Un Jung" last="Kang">Un Jung Kang</name>
<name sortKey="Kellendonk, Christoph" sort="Kellendonk, Christoph" uniqKey="Kellendonk C" first="Christoph" last="Kellendonk">Christoph Kellendonk</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000313 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000313 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    MovDisordV3
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:26018615
   |texte=   Balancing the basal ganglia circuitry: a possible new role for dopamine D2 receptors in health and disease.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:26018615" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a MovDisordV3

This area was generated with Dilib version V0.6.23.
Data generation: Sun Jul 3 12:29:32 2016. Site generation: Wed Feb 14 10:52:30 2024

Movement Disorders (revue)

Balancing the basal ganglia circuitry: a possible new role for dopamine D2 receptors in health and disease.

Balancing the basal ganglia circuitry: a possible new role for dopamine D2 receptors in health and disease.

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.